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A new Hantaan-like virus in rodents (Apodemus peninsulae) from Northeastern China
Jia-Fu Jiang1, Wen-Yi Zhang, Kun Yao
1Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, PR China.
Abstract:
Lung tissue samples of 76 Korean field mice (Apodemus peninsulae) collected from northeastern China bordering with Far East Russia and Korea were detected for hantavirus partial M-segment or entire S-segment sequences by RT-PCR and 481-nt mitochondrial DNA fragment of the rodents. Four A. peninsulae mice were found positive for partial M-segment of hantavirus. Sequence analyses of partial M-segment or/and entire S-segment of the hantaviruses revealed that three were closely related to Hantaan virus (HTNV) strain 76-118. One new variant of HTNV-like virus designated as "Jilin-AP06" was much different from other rodent-borne hantavirus from China, and clustered with Amur (AMR) virus strains, which represent a distinct genetic lineage. These findings imply that hantavirus Jililn-AP06 strain from A. peninsulae is a new record of rodent-borne AMR virus in China. A. peninsulae might be a natural carrier of two distinct hantaviruses, AMR virus and HTNV in China.
Insights
This study identified hantaviruses in Korean field mice in China. A new Amur virus variant and Hantaan virus were detected, suggesting mice carry distinct hantaviruses.
Area of Science:
- Virology
- Rodent-borne diseases
- Molecular epidemiology
Background:
- Hantaviruses are a significant public health concern.
- Rodents serve as natural reservoirs for hantaviruses.
- Surveillance of hantavirus in rodent populations is crucial for understanding transmission dynamics.
Purpose of the Study:
- To investigate the presence and genetic diversity of hantaviruses in Korean field mice (Apodemus peninsulae) in China.
- To identify novel hantavirus strains and their potential rodent hosts.
- To understand the genetic lineage and geographical distribution of hantaviruses in the region.
Main Methods:
- Collection and processing of lung tissue samples from 76 Apodemus peninsulae mice.
- Detection of hantavirus RNA using RT-PCR for partial M-segment and entire S-segment sequences.
- Phylogenetic analysis of obtained viral sequences and rodent mitochondrial DNA.
Main Results:
- Four out of 76 mice tested positive for hantavirus.
- Three positive samples showed sequences closely related to Hantaan virus (HTNV).
- One novel HTNV-like virus, designated "Jilin-AP06", was identified, clustering with Amur (AMR) virus strains, indicating a distinct genetic lineage.
Conclusions:
- Apodemus peninsulae mice in China can harbor distinct hantaviruses, including HTNV and a novel AMR virus variant.
- The discovery of the "Jilin-AP06" strain represents a new record of rodent-borne AMR virus in China.
- This finding highlights the potential of A. peninsulae as a natural carrier for multiple hantavirus species.
