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Updated: Jul 13, 2026
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
New prospects for management and treatment of inoperable and recurrent skull base meningiomas
Mahlon D Johnson1, Burak Sade, Michael T Milano
1Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Rochester Medical Center, 601 Elmwood Ave. Box 626, Rochester, NY 14623, USA. mahlon_johnson@urmc.rochester.edu
Abstract:
Skull base, including optic nerve, cavernous sinus, clival and foramen magnum tumors represent a major challenge for neurosurgeons and neuro-oncologists. Growth regulatory signaling pathways for these tumors are of increasing interest as potential targets for new chemotherapy. Those differentially activated in various grades of meningiomas are currently being identified as well. This article reviews some recent findings pathways that appear to regulate meningioma growth. Potential targets for novel therapies are also discussed.
Insights
Skull base tumors, including meningiomas, pose significant challenges. Researchers are identifying growth signaling pathways to develop new chemotherapy treatments targeting these complex brain tumors.
Area of Science:
- Neuro-oncology
- Molecular Biology
- Neurosurgery
Background:
- Skull base tumors, particularly meningiomas, present complex challenges for neurosurgeons and neuro-oncologists.
- Understanding tumor growth mechanisms is crucial for developing effective treatments.
- Signaling pathways regulating tumor proliferation are key areas of investigation.
Purpose of the Study:
- To review recent findings on signaling pathways involved in meningioma growth.
- To discuss potential therapeutic targets for novel chemotherapy strategies.
Main Methods:
- Literature review of recent research on meningioma growth pathways.
- Analysis of signaling pathways differentially activated in various meningioma grades.
Main Results:
- Identification of specific growth regulatory signaling pathways implicated in meningioma progression.
- Differential activation patterns of these pathways across different meningioma grades.
Conclusions:
- Targeting identified signaling pathways offers potential for novel chemotherapy in meningioma treatment.
- Further research into these pathways could lead to more effective therapeutic strategies for skull base tumors.
