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Updated: Jul 13, 2026
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Ex Vivo Perfusion of the Rodent Placenta
Published on: May 30, 2019
The human placenta--an alternative for studying foetal exposure
Maja Myren1, Tina Mose, Line Mathiesen
1Institute of Public Health, University of Copenhagen, Oester Farimagsgade 5, DK 1014 Copenhagen K, Denmark.
Summary
Pregnant women encounter numerous foreign substances daily. This review examines placental transfer of these compounds and their potential impact on fetal development, highlighting the need for further research.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
- Toxicology
Background:
- Pregnant women are exposed to diverse foreign substances from lifestyle, medication, and environmental factors.
- The placenta, crucial for nutrient and oxygen transport, also allows passage of some compounds to the fetus.
- Fetal exposure to these substances can affect growth and organ development.
Purpose of the Study:
- To review placental anatomy, development, and function.
- To evaluate the physical properties of compounds and their transfer mechanisms across the placental barrier.
- To discuss the necessity of comprehensive studies for assessing fetal risk.
Main Methods:
- Review of existing literature on placental transfer and fetal exposure.
- Evaluation of compound properties influencing placental transport.
- Discussion of in vivo and in vitro models, including placental perfusion systems.
Main Results:
- Foreign compounds cross the placental barrier to varying degrees.
- Placental transfer is influenced by compound properties and transfer mechanisms.
- Accurate fetal risk assessment requires understanding transport, toxicological targets, and effects.
Conclusions:
- Understanding placental transfer is vital for fetal health.
- Various models aid in studying compound transfer and effects.
- Further research is essential to determine fetal risks from maternal exposures.
