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Updated: Jul 13, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines
Mark A Elban1, Jean C Chapuis, Mei Li
1Departments of Chemistry and Biology, University of Virginia, Charlottesville, VA 22904, USA.
Abstract:
Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both natural products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described.
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