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Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and
D L A Rakotondramanana1, Mélanie Delomenède, Michel Baltas
1Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique, LSPCMIB, UMR-CNRS 5068, Université Paul Sabatier, 118, Route de Narbonne, 31062 Toulouse Cedex 9, France.
Abstract:
Oxidative dimerization of ferulic acid methyl ester afforded dihydrobenzofuran derivative and new linear compound identified by X-ray crystallography. The gallate derivatized dihydrobenzofuran analogue was obtained and all compounds were evaluated for potential antiatherogenic, antiplasmodial (best IC(50)=0.8 microM) and cytotoxic activities.
