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Related Experiment Video

Updated: Jul 13, 2026

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

Elevated circulating plasma adiponectin in underweight patients with COPD.

Koichi Tomoda¹, Masanori Yoshikawa, Takefumi Itoh

¹Second Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan. ktomoda@nmu-gw.naramed-u.ac.jp

|July 13, 2007

Summary

Elevated adiponectin levels in COPD patients correlate with lower body weight and inflammation. This finding may explain reduced cardiovascular risks in underweight COPD individuals.

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Last Updated: Jul 13, 2026

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

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Published on: September 5, 2025

Area of Science:

Endocrinology
Pulmonology
Immunology

Background:

Adiponectin, an adipose-derived protein, exhibits anti-inflammatory and anti-atherosclerotic properties.
Obesity is linked to cardiovascular diseases in US COPD patients, while cachexia and respiratory failure are common in Japanese COPD patients.
This study investigates adiponectin's role in these differing COPD characteristics.

Purpose of the Study:

To examine adiponectin levels in normal-weight and underweight male COPD patients.
To assess the correlation between adiponectin levels and pulmonary function.
To investigate the relationship between adiponectin and systemic inflammation markers.

Main Methods:

Enrolled 31 normal-weight/underweight male COPD patients and 12 healthy male controls.
Measured adiponectin levels using enzyme-linked immunosorbent assay (ELISA).
Correlated adiponectin with pulmonary function and serum cytokines (TNF-alpha, IL-6).

Main Results:

COPD patients had significantly higher adiponectin levels than controls (p<0.01).
Adiponectin levels inversely correlated with body mass index (BMI) (r = -0.55, p<0.01).
Elevated adiponectin correlated with hyperinflation (residual volume) and, in some cases, with TNF-alpha.

Conclusions:

Plasma adiponectin is elevated in COPD patients, linked to weight loss, hyperinflation, and inflammation.
Increased adiponectin may offer protection against cardiovascular events in underweight COPD individuals.