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Primary hyperparathyroidism presenting as multiple giant cell lesions.

B G Harsha Vardhan1, K Saraswathy, D Koteeswaran

  • 1Department of Oral Medicine and Radiology, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India. bgharshavardhan@yahoo.com

Quintessence International (Berlin, Germany : 1985)
|July 13, 2007
PubMed
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Giant cell lesions can be an early indicator of primary hyperparathyroidism. This case highlights the importance of considering metabolic bone disease in patients presenting with such lesions.

Area of Science:

  • Endocrinology
  • Oral and Maxillofacial Surgery
  • Pathology

Background:

  • Giant cell lesions, though uncommon, can manifest in the jaws.
  • Primary hyperparathyroidism is a metabolic disorder often associated with bone abnormalities.

Observation:

  • A 55-year-old woman presented with a 2-month history of swelling and pain in the upper-left posterior jaw.
  • Clinical examination revealed a localized swelling in the affected region.

Findings:

  • Radiological imaging showed a lesion consistent with a giant cell lesion.
  • Biochemical tests confirmed elevated parathyroid hormone levels, indicative of primary hyperparathyroidism.
  • Histopathological examination of the lesion confirmed the diagnosis of a giant cell lesion.

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Implications:

  • This case underscores the significance of giant cell lesions as a potential initial manifestation of primary hyperparathyroidism.
  • Early diagnosis and management of primary hyperparathyroidism are crucial to prevent further skeletal complications.
  • Multidisciplinary evaluation involving endocrinology, oral surgery, and pathology is recommended for similar presentations.