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Updated: Jul 13, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Does sodium nitroprusside kill babies? A systematic review.

Nelson Sass¹, Caroline Harumi Itamoto, Marina Pereira Silva

¹Obstetrics Department, Universidade Federal de São Paulo Escola Paulista de Medicina, Brazil. nelsonsa.alp@terra.com.br

Sao Paulo Medical Journal = Revista Paulista De Medicina

|July 13, 2007

Summary

This study found insufficient evidence to link sodium nitroprusside use with fetal death in pregnancies complicated by hypertension. More research is needed to establish a definitive association between this drug and adverse pregnancy outcomes.

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Last Updated: Jul 13, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Area of Science:

Perinatal medicine
Obstetrics
Pharmacology

Background:

Hypertension in pregnancy is a significant concern.
Sodium nitroprusside is used for hypertensive emergencies.

Purpose of the Study:

To investigate the association between sodium nitroprusside administration and fetal demise in pregnancies complicated by hypertension.

Main Methods:

Comprehensive literature search of multiple databases (MEDLINE, EMBASE, Web of Science, LILACS, Cochrane Library) from inception to 2003.
Included observational studies focusing on "nitroprusside and pregnancy" and "hypertension or eclampsia or preeclampsia" in humans.
References from articles and textbooks were also reviewed.

Main Results:

Nine observational studies were identified, encompassing 22 patients and 24 exposed fetuses.
No randomized clinical trials or prospective cohort studies were found.
All included studies were observational.

Conclusions:

There is currently insufficient evidence to definitively conclude a direct link between sodium nitroprusside use and fetal death.
Further research is required to establish causality and understand the risks in hypertensive pregnancies.