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Published on: June 14, 2019
International standard reagents for HPV detection.
Sonia R Pagliusi1, Suzanne M Garland
1Department of Immunizations, Vaccines and Biologicals, World Health Organization, Av Appia 20, 1211 Geneva 27, Switzerland. pagliusi@who.int
Disease Markers
|July 14, 2007
Summary
Human papillomavirus (HPV) detection assays are crucial for identifying HPV-associated diseases and monitoring vaccine impact. Standardized reagents ensure accurate, comparable global testing for cancer prevention and disease burden evaluation.
Area of Science:
- Virology
- Oncology
- Immunology
Background:
- Human papillomavirus (HPV) is the most common genital viral infection.
- Persistent HPV infection can indicate underlying conditions or predict future HPV-associated diseases.
- Detecting oncogenic HPV types is vital for disease prognosis and prevention.
Purpose of the Study:
- To outline various assays for detecting oncogenic HPV types.
- To discuss the development of international standard reagents for HPV detection.
- To emphasize the need for standardized tools for quality assessment of HPV detection systems.
Main Methods:
- Review of molecular, serological, and cellular markers for HPV detection.
- Discussion of assays based on HPV infection stages and viral life cycle.
- Outline of international standard reagents for qualitative and quantitative assessment.
Main Results:
- Various assays detect HPV nucleic acid sequences, antibodies, and intracellular proteins.
- International standard reagents are being developed for assay performance assessment.
- Standardization is essential for accurate and comparable global HPV testing.
Conclusions:
- Standardized HPV detection methods and reagents are critical for regulatory and clinical management.
- Accurate assays ensure reliable evaluation of disease burden, HPV vaccines, and cancer prevention.
- Advancements in HPV vaccines highlight the growing importance of reliable HPV detection assays.
