Calcium homeostasis: how bone solubility relates to all aspects of bone physiology

This perspective challenges the bone research community to study a new concept of calcium homeostasis and determine how it affects all aspects of bone physiology and disease. The concept started with Neuman's discovery that the apparent supersaturation of calcium in the extracellular fluid (ECF) could be explained by the presence of non-collagenous proteins on the surfaces of bone. His discovery opens the door to a new field of bone research and raises the question of how his result affects other aspects of bone physiology and pathology? The purpose of this perspective is to challenge the bone field to determine the significance of these findings. The report lists a few areas that need inquiry and supplies premises that need to be tested.