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Updated: Jul 13, 2026

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point

Published on: June 28, 2024

Primary pineal malignant melanoma.

Markus Bookland¹, W Stanley Anderson, Ann Biser-Rohrbaugh

¹Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. mbookla1@jhmi.edu

Pediatric Neurosurgery

|July 14, 2007

Summary

Primary pineal malignant melanoma is a rare and aggressive brain tumor. This case study details the treatment of a young patient with this rare neoplasm, including radiation and chemotherapy.

Area of Science:

Neuro-oncology
Rare tumors
Central nervous system neoplasms

Background:

Primary pineal malignant melanomas are an exceptionally rare form of primary central nervous system melanoma.
Malignant melanomas in the pineal region present unique diagnostic and therapeutic challenges.

Observation:

A case report of a 20-year-old female diagnosed with primary pineal region malignant melanoma.
The patient underwent endoscopic biopsy and received adjuvant therapy, including stereotactic and whole-brain radiation, and Temodar(R).
Refractory intracranial pressure (ICP) necessitated a ventriculo-peritoneal shunt.

Findings:

This case highlights the aggressive nature of pineal malignant melanoma.
Multimodal treatment including radiation and chemotherapy was employed for disseminated disease.

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Management of increased ICP is critical in these patients.

Implications:

This case contributes to the limited literature on primary pineal malignant melanoma.
Early diagnosis and aggressive, multimodal treatment strategies are essential for managing this rare neoplasm.
Further research is needed to optimize treatment protocols for primary central nervous system melanomas.