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Lipofuscin, homocysteine and tissue polypeptide specific antigen in gestational hypertension
Robert Partyka1, B Chmiel, Jerzy Sikora
1Department of Clinical Immunodiagnostics, Medical University of Silesia, Katowice, Poland.
Objective:
The aim of this study were to assess the levels of lipofuscin (parameter of oxidative stress), homocysteine (as a marker of vascular injury) and tissue specific antigen - TPS - (as a marker of cell proliferation) in relation to arterial pressure of pregnant woman.
Study Design:
Healthy pregnant women (n=18), women with mild 140/90=< RR<160/100 (n=19), and severe 160/100=
Results:
Mean duration of gestation was 34+/-5 weeks, and there were no differences between groups. Serum lipofuscin levels in mild form of pregnancy-induced hypertension were decreased comparing to normal pregnancy. Homocysteine levels were decreased and TPS levels increased in both mild and severe gestational hypertension.
Conclusion:
Our results suggest overestimation of the role of oxidative stress and hyperhomocysteinemia in gestational hypertension.
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