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Updated: Jul 13, 2026
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Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells
Published on: October 22, 2012
Interaction profiling of T-cell epitopes with MHC-class I molecules
Banaja Priyardarshini Dash1, Sumanto Mukherjee, V L Suhas
1Bioinformatics Centre and Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore, India.
Protein and Peptide Letters
|July 14, 2007
Summary
Understanding how T-cell receptors recognize antigens is crucial for vaccine design. This study analyzes peptide-human leukocyte antigen (HLA) structures to identify key features driving this recognition specificity.
Area of Science:
- Structural bioinformatics
- Immunology
- Vaccine development
Background:
- Rational vaccine design requires understanding antigen recognition by receptors.
- Crystal structures of Major Histocompatibility Complex (MHC) / Human Leukocyte Antigen (HLA) molecules provide insights into molecular interactions.
Purpose of the Study:
- To derive features that dictate peptide-HLA recognition specificity.
- To guide the rational design of vaccines through structural bioinformatics.
Main Methods:
- Structural bioinformatics analysis of peptide-HLA complexes.
- Investigation of molecular features governing antigen-receptor interactions.
Main Results:
- Identification of specific features within peptide-HLA complexes responsible for recognition.
- Derivation of principles for guiding vaccine design based on structural data.
Conclusions:
- Structural bioinformatics of peptide-HLA complexes is essential for understanding antigen recognition.
- The identified features can inform and enhance the rational design of vaccines.
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