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Related Experiment Video

Updated: Jul 13, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

Hepatitis B virus genotypes and subgenotypes in China.

Zhanhui Wang¹, Yuehua Huang, Shujuan Wen

¹Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Hepatology Research : the Official Journal of the Japan Society of Hepatology

|July 14, 2007

Summary

Hepatitis B virus (HBV) genotypes B and C are most common in China. Subgenotype Ba and C1/C2 show distinct distributions and mutation prevalence, impacting interferon treatment response.

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Area of Science:

Hepatology
Virology
Genetics

Background:

Hepatitis B virus (HBV) is a major global health concern, with China being a highly endemic area.
Chronic HBV infection prevalence in China ranges from 8-20% of the general population.
Genotypes B and C are the predominant HBV strains in China, accounting for approximately 95% of infections.

Purpose of the Study:

To investigate the distribution and characteristics of HBV genotypes and subgenotypes in China.
To analyze the prevalence of specific HBV mutations (A1896 and T1762/A1764) across different subgenotypes.
To compare the response rates to antiviral therapies based on HBV genotype.

Main Methods:

Nucleotide sequencing to identify HBV genotypes and subgenotypes.
Geographic and ethnic mapping of subgenotype distributions.
Prevalence analysis of specific HBV mutations.
Retrospective analysis of antiviral treatment response.

Main Results:

HBV genotype B strains in China belong to subgenotype Ba.
Two genotype C subgenotypes, C1 (Cs) and C2 (Ce), exhibit different geographic distributions.
Significant differences in A1896 and T1762/A1764 mutation prevalence were observed among HBV Ba, C1, and C2 subgenotypes (P < 0.001).
Chinese patients with HBV genotype B showed a higher response rate to interferon treatment compared to genotype C patients, with no difference observed for nucleoside/nucleotide analog treatment.

Conclusions:

HBV genotype and subgenotype distribution in China are characterized by predominant Ba, C1, and C2 strains with distinct geographic patterns.
Specific HBV mutations vary significantly across these subgenotypes.
Genotype influences the efficacy of interferon-based antiviral therapy for chronic HBV infection in China.