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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
Acute pyelonephritis in pregnancy: a retrospective study
1Department of Obstetrics and Gynecology, Patan Hospital, Lalitpur, Nepal.
Summary
Acute antepartum pyelonephritis, primarily caused by Escherichia coli, affects nulliparous women in their second trimester. Pregnancy outcomes were comparable to the general obstetric population, suggesting ceftriaxone as a preferred treatment.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Maternal-Fetal Medicine
Background:
- Acute antepartum pyelonephritis is a significant concern during pregnancy.
- Understanding its incidence, risk factors, and outcomes is crucial for maternal and fetal health.
Purpose of the Study:
- To determine the incidence and risk factors of acute antepartum pyelonephritis.
- To identify causative microbial pathogens and their antibiotic sensitivities.
- To compare pregnancy outcomes in affected women versus the general obstetric population.
Main Methods:
- Retrospective study of pregnant women admitted to Patan Hospital, Nepal.
- Analysis of 7034 deliveries over a one-year period.
- Comparison of pregnancy outcomes between pyelonephritis cases and controls.
Main Results:
- Incidence of acute antepartum pyelonephritis was 1.3% (94 cases).
- Most common in nulliparous women (75%) and during the second trimester (60%).
- Escherichia coli was the predominant pathogen (81%), sensitive to nitrofurantoin and ceftriaxone. No significant difference in low-birthweight or preterm birth rates was observed.
Conclusions:
- Acute pyelonephritis in pregnancy is most common in nulliparous women during the second trimester.
- Escherichia coli is the primary causative agent.
- Ceftriaxone is recommended as the drug of choice due to safety and efficacy.
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