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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Extracellular Matrix01:26

Extracellular Matrix

Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...

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Related Experiment Video

Updated: Jul 13, 2026

Biological Preparation and Mechanical Technique for Determining Viscoelastic Properties of Zonular Fibers
06:39

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Published on: December 16, 2021

Ageing in Marfan syndrome.

A Hasan1, J Poloniecki, A Child

  • 1Department of Cardiological Sciences, St. George's, University of London, London, UK.

International Journal of Clinical Practice
|July 14, 2007
PubMed
Summary

Older adults with Marfan syndrome (MFS) face increased risks of eye and heart complications, including retinal detachment and cardiovascular issues. Early medical intervention is crucial due to the condition's degenerative nature.

Area of Science:

  • Genetics
  • Connective Tissue Disorders
  • Geriatric Medicine

Background:

  • Marfan syndrome (MFS) is a genetic disorder affecting connective tissue.
  • Historically, research focused on younger MFS patients due to reduced lifespan.
  • Older MFS survivors present unique challenges and require specific medical attention.

Purpose of the Study:

  • To investigate the spectrum of medical complications in older adults (50+ years) with Marfan syndrome.
  • To identify ocular, cardiovascular, and musculoskeletal issues in aging MFS patients.
  • To compare the health status of older MFS patients with age- and sex-matched controls.

Main Methods:

  • Analysis of 156 questionnaires from patients aged 50+ in the National Marfan Syndrome Clinical Database.

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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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  • Inclusion of 60 eligible MFS patients (median age 57) and 56 controls.
  • Collection of data on medical history, including eye, heart, and musculoskeletal conditions, via patient and control questionnaires.

    • Main Results:

    • Patients over 50 with MFS showed a higher risk of retinal detachment (24%) and cardiovascular abnormalities (42% post-aortic surgery, 53% palpitations).
    • Cataract was a notable complication, reported by 27% of MFS patients.
    • The study highlights lesser-known complications in older MFS populations.

    Conclusions:

    • Medical practitioners must recognize the diverse complications in aging MFS patients beyond typical aging.
    • Proactive investigation and tailored therapies are essential for MFS patients over 50.
    • The degenerative nature of Marfan syndrome necessitates earlier intervention compared to the general aging population.