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Updated: Jul 13, 2026

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
Published on: January 26, 2018
Hormonal signaling and signal pathway crosstalk in the control of myometrial calcium dynamics
1Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1680, USA. Barbara.Sanborn@colostate.edu
Abstract:
Understanding the basis for the control of myometrial contractant and relaxant signaling pathways is important to understanding how to manage myometrial contractions. Signaling pathways are influenced by the level of expression of the signals and signal pathway components, the location of these components in the appropriate subcellular environment, and covalent modification. Crosstalk between these pathways regulates the effectiveness of signal transduction and represents an important way by which hormones can regulate phenotype. This review deals primarily with signaling pathways that control Ca2+ entry and intracellular release, as well as the interplay between these pathways.
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