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Updated: Jul 13, 2026
08:13
Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
Recombinant activated factor VII: current perspectives and Epworth experience.
Matthew P Labattaglia1, Benno Ihle
1Intensive Care Unit, Epworth Hospital, 89 Bridge Road, Richmond, Melbourne, Victoria 3121, Australia.
Heart, Lung & Circulation
|July 14, 2007
Summary
Recombinant factor VII (rFVII) effectively controls bleeding in hemophilia. Its off-label use is expanding for trauma, surgery, and obstetric bleeding, with initial positive surgical outcomes noted.
Area of Science:
- Hematology
- Pharmacology
Background:
- Recombinant factor VII (rFVII) was initially developed for hemophilia patients with inhibitors to factors VIII or IX.
- Its established efficacy in hemophilia is well-documented.
Purpose of the Study:
- To describe the mechanism of action of rFVII.
- To review the current literature on off-label rFVII usage.
- To present initial experiences with rFVII in surgical bleeding cases at Epworth Hospital.
Main Methods:
- Literature review of off-label rFVII applications.
- Analysis of initial clinical experience in surgical bleeding.
Main Results:
- Established efficacy of rFVII in hemophilia.
- Growing trend of off-label rFVII use in various bleeding scenarios.
- Initial positive outcomes observed in surgical bleeding cases.
Conclusions:
- rFVII demonstrates established efficacy in hemophilia.
- Off-label applications of rFVII in trauma, surgery, and obstetrics are increasing.
- Further investigation into off-label rFVII use is warranted.
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