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Updated: Jul 13, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
Studies toward the synthesis of pinnatoxins: the B,C,D-dispiroketal fragment
1Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306-4390, USA.
Abstract:
A stereoselective synthesis of the tricyclic B,C,D-dispiroketal fragment of pinnatoxins is described. Both products of an efficient enzymatic resolution reaction are used to set the stereochemistry of C12 and C23, which have opposite configuration. The configuration of the ketal centers is established upon an optimized thermodynamically controlled spiroketalization.
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