Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The alpha-tocopherol transfer protein.

D Manor1, S Morley

  • 1Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.

Vitamins and Hormones
|July 14, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toward optimizing patient selection for EGFR antibody therapies in metastatic colorectal cancer: outcomes and resistance features in real-world data.

ESMO real world data and digital oncology·2026
Same author

Three-dimensional anatomical model of the facial nerve in 100 parotid tumours: improved planning and personalised surgery.

The British journal of oral & maxillofacial surgery·2025
Same author

Rethinking the 'one-stop' neck lump clinic: a novel pathway beyond coronavirus disease 2019.

The Journal of laryngology and otology·2023
Same author

The tocopherol transfer protein mediates vitamin E trafficking between cerebellar astrocytes and neurons.

The Journal of biological chemistry·2022
Same author

Trans-oral ultrasound-guided biopsy for head and neck lesions: an alternative for lesions not amenable to standard percutaneous image-guided biopsy. Description of the technique and case series.

Clinical radiology·2021
Same author

The use of computed tomography as a first-line imaging modality in patients with primary hyperparathyroidism.

Hormones (Athens, Greece)·2020
Same journal

Bilateral macronodular and micronodular hyperplasia: Biochemical, radiological and genetic diagnosis.

Vitamins and hormones·2026
Same journal

ACTH independent Cushing's syndrome: Diagnosis and etiology.

Vitamins and hormones·2026
Same journal

Biochemical diagnosis of hypercortisolism: When and how?

Vitamins and hormones·2026
Same journal

New tools for the diagnosis of hypercortisolism.

Vitamins and hormones·2026
Same journal

Cardiometabolic comorbidities in overt Cushing's syndrome.

Vitamins and hormones·2026
Same journal

Molecular profile of Cushing's syndrome.

Vitamins and hormones·2026
See all related articles

Vitamin E is vital for fertility and preventing neurodegeneration. The alpha-tocopherol transfer protein (TTP) regulates vitamin E levels, and its gene mutations cause ataxia with vitamin E deficiency (AVED).

Area of Science:

  • Biochemistry
  • Neuroscience
  • Genetics

Background:

  • Plant extracts were historically linked to rodent fertility, later identified as vitamin E, a group of fat-soluble antioxidants.
  • The alpha-tocopherol transfer protein (TTP) is essential for regulating vitamin E (tocopherol) levels in the body.
  • Mutations in the TTP gene lead to ataxia with vitamin E deficiency (AVED), a disorder causing neurodegeneration.

Purpose of the Study:

  • To summarize recent advancements in understanding the molecular and physiological functions of TTP.
  • To elucidate the role of TTP in vitamin E regulation and its implications in neurological health.

Main Methods:

  • Review of existing literature on TTP function and AVED.
  • Analysis of molecular mechanisms underlying TTP activity.

Related Experiment Videos

  • Examination of physiological consequences of TTP dysfunction.

    • Main Results:

    • TTP facilitates vitamin E transport between cellular membranes and its secretion from liver cells (hepatocytes).
    • Heritable TTP gene mutations result in significantly reduced plasma vitamin E levels.
    • TTP dysfunction is directly linked to progressive neurodegeneration observed in AVED patients.

    Conclusions:

    • TTP plays a critical role in maintaining adequate vitamin E status.
    • Understanding TTP's molecular and physiological functions is key to addressing AVED.
    • Further research into TTP activity may offer therapeutic insights for neurodegenerative disorders.