Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vitamin E and cancer.

Kimberly Kline1, Karla A Lawson, Weiping Yu

  • 1Division of Nutrition, University of Texas at Austin, Texas 78712, USA.

Vitamins and Hormones
|July 14, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive analysis suggests CRIF1 is a potential target in breast cancer associated with prognosis and immune infiltration.

Annals of medicine·2026
Same author

EMP3 Expression in HER2-Enriched Breast Cancer is Linked to PI3K/AKT Signaling and Indicates Poor Prognosis.

Genetics research·2026
Same author

An exploratory within-cohort paired comparison study of learner-centered and traditional teaching in medical endocrinology education.

BMC research notes·2026
Same author

Outcomes of pediatric blunt liver and spleen injury in 1029 patients using the ATOMAC+ pediatric trauma research network guideline.

Journal of pediatric surgery·2026
Same author

Physical abuse of young children reported by medical professionals in the United States 2014-2023.

Frontiers in pediatrics·2026
Same author

Implementing an Education Intervention for Prescription Opioid Pain Medication at Pediatric Trauma Centers.

Substance use & misuse·2026

While common vitamin E forms failed as cancer treatments in trials, novel vitamin E analogues show promise. Preclinical studies suggest these compounds may offer potent anticancer effects by promoting apoptosis.

Area of Science:

  • Biochemistry
  • Oncology
  • Nutritional Science

Background:

  • Vitamin E, known for antioxidant properties, was investigated for various health benefits, including cancer prevention.
  • Recent clinical trials have not substantiated vitamin E's efficacy as a potent anticancer agent.
  • Less common forms of vitamin E and novel analogues warrant further investigation for anticancer potential.

Purpose of the Study:

  • To review natural and synthetic vitamin E compounds and analogues.
  • To summarize human intervention trials on vitamin E and cancer.
  • To examine preclinical data on vitamin E compounds and analogues for cancer treatment.
  • To elucidate the anticancer mechanisms of vitamin E-based compounds, focusing on apoptosis.

Main Methods:

Related Experiment Videos

  • Review of existing literature on vitamin E, clinical trials, and preclinical studies.
  • Analysis of data from cell culture and animal models.
  • Examination of molecular mechanisms related to apoptosis and cell survival signaling.

    • Main Results:

    • Established vitamin E forms (RRR-alpha-tocopherol, all-rac-alpha-tocopherol) lack evidence of anticancer efficacy from clinical trials.
    • Preclinical studies indicate that less-studied vitamin E forms and novel analogues exhibit potential as anticancer agents.
    • Mechanistic studies reveal proapoptotic effects, including restoring apoptotic pathways and blocking survival signals.

    Conclusions:

    • Standard vitamin E forms are not supported as anticancer agents by current clinical evidence.
    • Novel vitamin E analogues demonstrate promise in preclinical cancer research.
    • Understanding the proapoptotic mechanisms of vitamin E compounds is crucial for developing future cancer therapies.