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[Natural tyrosine-kinase inhibitors]
1Centre de Pharmacologie-Endocrinologie, CNRS-INSERM, Montpellier, France.
Pathologie-Biologie
|October 1, 1991
Summary
Naturally occurring protein tyrosine-kinase (PTK) inhibitors, like PP 63, show potential as anti-cancer agents by reducing cell phosphorylation and growth. Further research is needed to clarify their physiological roles.
Area of Science:
- Biochemistry
- Cell Biology
- Molecular Biology
Context:
- Protein tyrosine phosphorylation is crucial for cell growth and differentiation.
- Enzyme systems regulating phosphorylation (protein tyrosine-kinases and phosphatases) are poorly understood.
- Natural effectors can modulate these enzyme systems.
Purpose:
- To review current knowledge on natural protein tyrosine-kinase (PTK) inhibitors.
- To highlight identified natural PTK inhibitors and their effects.
- To explore the potential of these inhibitors in therapeutic applications.
Summary:
- Several natural proteins, including phosphoprotein PP 63, protein S-100, and a factor from human lymphoid tissues, exhibit anti-PTK activity.
- PP 63 inhibits insulin-receptor PTK and blocks insulin's mitogenic effect.
- These inhibitors decrease protein tyrosine phosphorylation, suggesting a role in regulating cell proliferation.
Impact:
- Identified natural PTK inhibitors may serve as potential anti-oncogenic agents.
- Understanding these inhibitors could lead to novel cancer therapies.
- Further investigation into their physiological roles is warranted.