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Published on: December 2, 2015
Frontal dysfunction during a cognitive task in drug-naive patients with panic disorder as investigated by
Yukika Nishimura1, Hisashi Tanii, Masato Fukuda
1Department of Psychiatry, Division of Neuroscience, Mie University, Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, Japan. ynishimu@clin.medic.mie-u.ac.jp
Abstract:
The present study investigated oxygenated ([oxy-Hb]) and deoxygenated ([deoxy-Hb]) hemoglobin concentration changes during the performance of a word fluency task in the frontal region of five drug-naive patients with panic disorder with or without agoraphobia and in 33 age-, sex-, and task performance-matched healthy volunteers by using multi-channel near-infrared spectroscopy (NIRS). The left inferior frontal [oxy-Hb] changes during performance of the task in patients with panic disorder were significantly smaller than those of healthy controls. This pilot study suggests the possibility that the left frontal lobe, required for cognitive function, is impaired in patients with panic disorder.
