[Therapy indications and options for skeletal metastases]

Area of Science:

• Orthopedics
• Oncology
• Radiology

Context:

• Pathological fractures are a significant complication of skeletal metastasis.
• Advances in oncological therapies and radiological techniques (MRI, PET) enhance multimodal treatment strategies.
• Surgical intervention decisions are multifactorial, considering primary disease, patient condition, and prognosis.

Purpose:

• To outline the current approach to managing pathological fractures secondary to skeletal metastasis.
• To highlight the role of modern oncological and radiological advancements in treatment planning.
• To define the primary goals of surgical intervention in these complex cases.

Summary:

• Pathological fractures due to skeletal metastasis pose a major clinical challenge.
• Multimodal treatment concepts have been significantly improved by modern oncological therapies and advanced radiological imaging like MRI and PET.
• Surgical treatment is individualized based on the primary malignancy, patient's overall health, and life expectancy, aiming to improve quality of life, alleviate pain, and preserve mobility.

Impact:

• Improved understanding of multimodal treatment for pathological fractures.
• Enhanced patient outcomes through optimized surgical interventions.
• Better quality of life and pain management for patients with skeletal metastasis.