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Updated: Jul 13, 2026
13:45
Merkel Cell Polyomavirus Infection and Detection
Published on: February 7, 2019
[Merkel cell carcinoma--clinically often misjudged]
H Weisser1, W Hartschuh, A Greiner
1Hautklinik, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
Deutsche Medizinische Wochenschrift (1946)
|July 14, 2007
Summary
Merkel cell carcinoma is a rare, aggressive skin cancer. Early, intensive treatment including radiation may improve survival rates for this challenging diagnosis.
Area of Science:
- Dermatology
- Oncology
- Pathology
Context:
- Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer.
- It predominantly affects sun-exposed skin in older individuals.
- MCC has a high propensity for metastasis and recurrence, leading to a poor prognosis.
Purpose:
- To provide a comprehensive overview of Merkel cell carcinoma.
- To discuss diagnostic methods, including histology and immunohistochemistry.
- To outline current and potential therapeutic strategies.
Summary:
- Histologically, MCC presents as trabecular nests of small cells with neuroendocrine features.
- Diagnosis is confirmed via immunohistochemistry using neuroendocrine and epithelial markers.
- First-line treatment involves primary tumor excision, often followed by adjuvant radiotherapy, including nodal basins.
Impact:
- Despite aggressive treatment, the 5-year survival rate is approximately 65%.
- Adjuvant chemotherapy may be considered for nodal disease, though its prognostic benefit is unproven.
- Aggressive, individualized treatment, particularly in early stages, holds promise for improving outcomes in Merkel cell carcinoma.
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