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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

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Related Experiment Video

Updated: Jul 13, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Stem cells for mesothelial repair: an understudied modality.

P A Lucas1

  • 1Department of Orthopaedic Surgery, New York Medical College, Valhalla, NY 10595, USA. Paul_Lucas@nymc.edu

The International Journal of Artificial Organs
|July 14, 2007
PubMed
Summary

Abdominal adhesions, a common surgical complication, may be prevented using stem cells. Research suggests adult stem cells from muscle tissue can differentiate into mesothelial cells, aiding wound repair and preventing adhesion formation.

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07:06

Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta

Published on: April 3, 2017

Area of Science:

  • Regenerative Medicine
  • Surgical Innovation
  • Stem Cell Biology

Background:

  • Abdominal adhesions are fibrous scar tissue bands that restrict organ movement, affecting over 75% of patients post-laparotomy.
  • Adhesion formation results from incomplete mesothelial healing after surgical injury.
  • The unique healing properties of the peritoneum suggest a role for stem cells.

Purpose of the Study:

  • To investigate the role of stem cells in peritoneal wound healing.
  • To explore the potential of adult stem cells for preventing abdominal adhesions.

Main Methods:

  • Review of existing studies on mesothelial healing and stem cell involvement.
  • Analysis of research on autologous mesothelial cells and multipotent adult stem cells from skeletal muscle for adhesion prevention.

Main Results:

  • Peritoneal wound healing occurs at a consistent rate, irrespective of size, implying mechanisms beyond simple cell proliferation.
  • Evidence suggests the presence of mesothelial stem cells or that mesothelial cells possess stem cell properties.
  • Adult stem cells from underlying muscle tissue can differentiate into mesothelial cells and contribute to healing.

Conclusions:

  • Stem cells play a crucial role in the repair of the mesothelium.
  • Utilizing adult stem cells from non-serosal sources presents a promising alternative strategy for preventing abdominal adhesions.