Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

Cognitive Development During Adulthood

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

Alzheimer Disease ll: Pathophysiology

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Modulation of relative aversive and safety learning by D2-expressing neurons of the anterior paraventricular nucleus of the thalamus.

Current biology : CB·2025

Same author

Targeting adult-born neurons to correct early deficits in pattern separation in the Tg2576 mouse model of Alzheimer's disease.

Neurobiology of disease·2025

Same author

Enriched environment requires the remodeling of hippocampal perineuronal nets to trigger memory improvement in Alzheimer's mouse model.

iScience·2025

Same author

Nociceptin/OrphaninFQ Receptor Modulates the Maturation of Adult-Born Neurons in the Mouse Dentate Gyrus Under Physiological Conditions and in a Chronic Stress Model.

Molecular neurobiology·2025

Same author

Fine social discrimination of siblings in mice: Implications for early detection of Alzheimer's disease.

Neurobiology of disease·2025

Same author

Adult brain neurogenesis does not account for behavioral differences between solitary and social bees.

Journal of insect physiology·2024

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

Immunohistochemistry and Multiple Labeling with Antibodies from the Same Host Species to Study Adult Hippocampal Neurogenesis

Immunohistochemistry and Multiple Labeling with Antibodies from the Same Host Species to Study Adult Hippocampal Neurogenesis

Published on: April 22, 2015

Hippocampal neurogenesis during normal and pathological aging.

Laure Verret¹, Stéphanie Trouche, Meike Zerwas

¹CNRS UMR 5169, Centre de Recherches sur la Cognition Animale, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 4, France.

Psychoneuroendocrinology

|July 17, 2007

Summary

New neurons are generated throughout life, even during aging. Research suggests promoting this neurogenesis could help improve cognitive function in normal aging and Alzheimer

More Related Videos

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Published on: August 20, 2020

Related Experiment Videos

Last Updated: Jul 13, 2026

Immunohistochemistry and Multiple Labeling with Antibodies from the Same Host Species to Study Adult Hippocampal Neurogenesis

Immunohistochemistry and Multiple Labeling with Antibodies from the Same Host Species to Study Adult Hippocampal Neurogenesis

Published on: April 22, 2015

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Published on: August 20, 2020

Area of Science:

Neuroscience
Cell Biology
Aging Research

Background:

Adult neurogenesis, the creation of new neurons, occurs in the brain throughout life, including during aging.
The hippocampus, crucial for memory, is a key site for adult neurogenesis.
This process is thought to support cognitive functions, but its role in aging and disease is under investigation.

Purpose of the Study:

To explore the persistence of neurogenesis in the aging brain, particularly in the context of Alzheimer's disease (AD).
To assess the potential of neurogenesis for cognitive function and therapeutic interventions in aging and AD.

Main Methods:

Analysis of human post-mortem tissues.
Studies using mouse models of Alzheimer's disease.

Main Results:

Evidence indicates that the capacity for hippocampal proliferation persists even during pathological aging.
Findings suggest that neurogenesis may continue in Alzheimer's disease (AD) brains, though the maturity of these neurons is yet to be confirmed.

Conclusions:

The persistent proliferative capacity in the aging hippocampus, including in AD, offers potential for cell-replacement therapies.
Strategies to enhance neurogenesis may serve as a therapeutic approach to mitigate cognitive decline associated with normal and pathological aging.