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Daptomycin

David A Enoch1, Jeanine M Bygott, Marie-Louise Daly

  • 1Clinical Microbiology and Public Health Laboratory, Health Protection Agency East of England, Papworth Hospital, Papworth Everard, Cambridgeshire, UK.

The Journal of Infection
|July 17, 2007
PubMed

Insights

Daptomycin is an effective antibiotic for Gram-positive infections, including resistant strains. While antimicrobial resistance is rising, daptomycin remains safe and well-tolerated, with further research needed for specific conditions.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Microbiology

Background:

  • Increasing prevalence of resistant Gram-positive pathogens.
  • Concerns regarding glycopeptide effectiveness against Staphylococcus aureus infections.
  • Emergence of multi-resistant bacterial strains necessitates alternative treatments.

Purpose of the Study:

  • To review the efficacy and safety of daptomycin as a treatment for Gram-positive bacterial infections.
  • To highlight daptomycin's role in managing infections caused by resistant pathogens.
  • To discuss current and potential future applications of daptomycin.

Main Methods:

  • Review of existing clinical data and licensed indications for daptomycin.
  • Analysis of daptomycin's pharmacokinetic and pharmacodynamic properties.
  • Assessment of safety and tolerability profiles based on clinical use.

Main Results:

  • Daptomycin demonstrates activity against Gram-positive organisms, including multi-resistant strains.
  • Licensed for complicated skin and soft tissue infections (4mg/kg daily) and S. aureus bacteraemia/endocarditis (6mg/kg daily).
  • Generally safe and well-tolerated at current dosing regimens, with relatively rare antimicrobial resistance.

Conclusions:

  • Daptomycin is a valuable therapeutic option for Gram-positive infections, especially those involving resistant organisms.
  • Further investigation is warranted for its use in osteomyelitis, septic arthritis, and combination therapies.
  • Continued monitoring of antimicrobial resistance patterns is crucial.

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