Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple sclerosis and Capgras' syndrome.

Vincenzo Sidoti1, Lorenzo Lorusso

  • 1Multiple Sclerosis Centre, Neurology Department, Mellino Mellini Hospital, V.le Mazzini 6, 25032 Chiari, Brescia, Italy. VincenzoSidoti@hotmail.com

Clinical Neurology and Neurosurgery
|July 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antonio D'Ormea (1873-1952) and encephalitis lethargica: the Italian psychiatrist who drew attention to childhood aspects of the disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

150 Years of the Iconographie photographique de la Salpêtrière: technical constraints and the shaping of medical images.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Updated Italian norms for the Paired-Associate Learning Test (PALT).

Aging clinical and experimental research·2026
Same author

Vincenzo Neri and the visual culture of wartime neuropsychiatry (1914-1918).

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Recurrent amiodarone-induced nystagmus, ataxia, and dysphagia: a case report.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

From testicles to brain: Understanding Dante's dream through medieval medicine.

Journal of the history of the neurosciences·2025
Same journal

Clinical response after cerebrospinal fluid shunting in complex versus pure idiopathic normal pressure hydrocephalus: A systematic review and meta-analysis.

Clinical neurology and neurosurgery·2026
Same journal

Preoperative sleep medication use and outcomes following lumbar spine surgery.

Clinical neurology and neurosurgery·2026
Same journal

Long-term real-world outcomes and device management of intrathecal drug delivery systems: A 16-year single-center experience with a primary focus on baclofen therapy.

Clinical neurology and neurosurgery·2026
Same journal

Trends and safety of outpatient versus inpatient lumbar interbody fusion - A national cohort study.

Clinical neurology and neurosurgery·2026
Same journal

A case report on αIN antibody-mediated paraneoplastic cerebellar ataxia.

Clinical neurology and neurosurgery·2026
Same journal

Early prediction of prolonged mechanical ventilation in invasively ventilated patients with subarachnoid hemorrhage: A MIMIC-IV prediction model study.

Clinical neurology and neurosurgery·2026
See all related articles

Multiple sclerosis (MS) patients rarely experience psychotic disorders. This case highlights a rare instance of Capgras' syndrome, a delusional misidentification, in an MS patient following steroid treatment.

Area of Science:

  • Neurology
  • Psychiatry

Background:

  • Psychotic disorders are uncommon in multiple sclerosis (MS).
  • While manic psychosis is more frequent, pure paranoid states are rare.
  • Capgras' syndrome, a specific delusional misidentification, is exceptionally rare in MS.

Observation:

  • A 36-year-old female with a history of MS since age 18 developed psychiatric symptoms after high-dose steroid treatment for optic neuritis.
  • Initial symptoms included delusions of reference, treated with clozapine.
  • Following a relapse with ataxia and corticosteroid treatment, she developed a paranoid disorder with persecutory delusions, specifically Capgras' syndrome towards her husband.

Findings:

  • The patient presented with Capgras' syndrome, a rare manifestation of psychosis in multiple sclerosis.

Related Experiment Videos

  • Psychiatric symptoms, including delusions, emerged after corticosteroid therapy for optic neuritis.
  • Treatment with glatiramer acetate and quetiapine led to improvement in her neuropsychiatric condition.

    • Implications:

    • This case underscores the importance of considering rare psychiatric complications like Capgras' syndrome in multiple sclerosis patients, particularly after steroid use.
    • It highlights the complex interplay between neurological disease, psychiatric symptoms, and treatment side effects in MS.
    • Effective management may involve a combination of immunomodulatory and antipsychotic therapies tailored to the individual patient.