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Prevention of Further Absorption of Poison

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In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...

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Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...

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Related Experiment Video

Updated: Jul 13, 2026

Ice Generation and the Heat and Mass Transfer Phenomena of Introducing Water to a Cold Bath of Brine

Ice Generation and the Heat and Mass Transfer Phenomena of Introducing Water to a Cold Bath of Brine

Published on: March 13, 2017

Ethylene glycol poisoning.

Mila Lovrić¹, Paula Granić, Mirjana Cubrilo-Turek

¹Clinical Institute of Laboratory Diagnosis, Zagreb University Hospital Center, Kispatićeva 12, Zagreb, Croatia. lovricm@kbc-zagreb.hr <lovricm@kbc-zagreb.hr>

Forensic Science International

|July 17, 2007

Summary

Antifreeze poisoning, often presenting with metabolic acidosis and unrecognized crystals, requires prompt treatment. Ethanol and hemodialysis effectively managed this severe ethylene glycol poisoning case, leading to full recovery.

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Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities

Published on: May 27, 2015

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Last Updated: Jul 13, 2026

Ice Generation and the Heat and Mass Transfer Phenomena of Introducing Water to a Cold Bath of Brine

Ice Generation and the Heat and Mass Transfer Phenomena of Introducing Water to a Cold Bath of Brine

Published on: March 13, 2017

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities

Published on: May 27, 2015

Area of Science:

Toxicology
Emergency Medicine
Nephrology

Background:

Ethylene glycol poisoning is a life-threatening condition often resulting from intentional ingestion.
Early diagnosis can be challenging due to non-specific initial symptoms and negative standard toxicological screens.

Observation:

A 40-year-old male presented in a coma after ingesting antifreeze, exhibiting metabolic acidosis, leukocytosis, hematuria, and unrecognized crystals on urinalysis.
Initial toxicological screening was negative, and osmolality/osmol gap were not measured upon admission.

Findings:

Elevated serum and urine levels of glycolic and oxalic acids, confirmed by ion-chromatography, indicated ethylene glycol poisoning.
Treatment with ethanol (antidote) and hemodialysis led to a significant decrease in toxic acid levels and clinical improvement.

Implications:

This case highlights the importance of considering ethylene glycol poisoning in patients with unexplained metabolic acidosis and specific urinalysis findings, even with negative initial screens.
Prompt administration of ethanol and hemodialysis is crucial for managing severe ethylene glycol poisoning and achieving complete recovery.