Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GLASS-seq: a gel-anchored, ligation-assisted, scalable biosensing platform for low-cost regional spatial transcriptomics.

Biosensors & bioelectronics·2026
Same author

Epigenetic compartmentalization of mitotic chromosomes by phase-separation-driven repulsion between WDR5 and the chromosomal passenger complex.

Nature communications·2026
Same author

Spindle neurons in human cortex possess distinctive firing properties and transcriptomic signatures.

Nature communications·2026
Same author

Aromatic guest-induced layer expansion and phase switching in a 2D square lattice coordination network.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

Arabidopsis Circadian Clock Protein CCA1 Negatively Regulates the Calcium-Binding Protein CCaP1 to Modulate Dark-Responsive Stomatal Movement.

Plant, cell & environment·2026
Same author

Suppressing laser-power noise with a multifunctional liquid crystal polarization grating in miniaturized optically pumped magnetometers.

Microsystems & nanoengineering·2026

Related Experiment Video

Updated: Jul 13, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Dark rearing alters the short-term synaptic plasticity in visual cortex.

Ai-Hui Tang1, Zhen Chai, Shi-Qiang Wang

  • 1State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China.

Neuroscience Letters
|July 17, 2007
PubMed
Summary

Sensory experience shapes brain development. Dark rearing in rats increased inhibitory postsynaptic current depression, suggesting a compensatory mechanism for immature visual cortex networks.

More Related Videos

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light
11:36

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light

Published on: February 10, 2017

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
08:42

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Published on: February 8, 2020

Related Experiment Videos

Last Updated: Jul 13, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light
11:36

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light

Published on: February 10, 2017

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
08:42

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Published on: February 8, 2020

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Sensory Development

Background:

  • Synaptic strength is modulated by recent activity (short-term plasticity).
  • Sensory experience is critical for the maturation of cortical circuits and function.

Purpose of the Study:

  • To investigate the impact of sensory experience on short-term synaptic plasticity in the rat visual cortex.
  • To determine if dark rearing affects synaptic plasticity in developing visual circuits.

Main Methods:

  • Whole-cell recordings were used to examine pyramidal neuron responses in layer V of rat visual cortex slices.
  • Repetitive stimulation was applied to layer II/III.
  • Rats were reared in a dark environment to deprive them of visual experience.

Main Results:

  • Dark rearing (DR) did not alter paired-pulse interactions of excitatory postsynaptic currents (EPSCs) or inhibitory postsynaptic currents (IPSCs).
  • DR significantly increased steady-state depression of IPSCs at stimulation frequencies of 20 Hz and above.
  • Dark rearing reduced the overall excitability of the visual cortex neural circuit.

Conclusions:

  • Dark rearing alters short-term synaptic plasticity, specifically enhancing inhibitory postsynaptic current depression.
  • These findings suggest a compensatory mechanism in the visual cortex to enhance network excitability when synaptic development is impaired due to lack of sensory input.