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Related Concept Videos

Transcription Factors02:16

Transcription Factors

82.7K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Transcription Elongation Factors02:35

Transcription Elongation Factors

13.8K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
13.8K
Transcription Elongation Factors02:35

Transcription Elongation Factors

4.8K
No description available
4.8K
General Transcription Factors01:30

General Transcription Factors

7.0K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
7.0K
Transcription01:10

Transcription

156.1K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
156.1K
Master Transcription Regulators02:23

Master Transcription Regulators

7.8K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K

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Related Experiment Video

Updated: Jan 30, 2026

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish
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Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

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MiT transcription factor associated malignancies in man.

Ian J Davis1, David E Fisher

  • 1Division of Hematology/Oncology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7295, USA. ian_davis@med.unc.edu

Cell Cycle (Georgetown, Tex.)
|July 17, 2007
PubMed
Summary

Recurrent genetic changes in cancer cells reveal new oncogenes. Aberrant activity of MiT transcription factors is a common mechanism driving multiple human solid tumors.

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Recurrent genetic abnormalities in cancer cells frequently identify novel oncogenic genes.
  • Understanding these alterations provides insights into oncogenic mechanisms.
  • Common genetic alterations include amplification, translocation, deletion, and point mutation, affecting gene function.

Purpose of the Study:

  • To investigate the role of MiT transcription factors in cancer.
  • To identify common genetic strategies leading to MiT family dysregulation in solid tumors.
  • To define a family of human solid tumors based on shared dependence on aberrant MiT activity.

Main Methods:

  • Analysis of genetic abnormalities in cancer cells.
  • Review of recent studies on MiT transcription factor family dysregulation.
  • Identification of convergent genetic strategies impacting MiT activity.

Main Results:

  • Multiple genetic strategies converge to dysregulate MiT transcription factor family members in cancer.
  • Aberrant MiT activity is a shared characteristic across an expanding group of human solid tumors.

Conclusions:

  • Dysregulation of the MiT transcription factor family is a key mechanism in a growing number of human solid tumors.
  • Identifying shared oncogenic pathways, like aberrant MiT activity, can define new therapeutic strategies for cancer treatment.