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A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
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Enhanced and resumed GB virus C replication in HIV-1-infected individuals receiving HAART

Per Björkman1, Leo Flamholc, Vilma Molnegren

  • 1Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden.

AIDS (London, England)
|July 17, 2007
PubMed

In patients co-infected with HIV-1 and GB virus C (GBV-C), the disappearance of GBV-C RNA has been associated with accelerated disease progression. We studied longitudinal GBV-C viral titres in 28 HIV-1/GVB-C co-infected individuals receiving HAART. During HAART, median GBV-C RNA titres increased from 95 to 6000 copies/ml (P < 0.001). In patients interrupting HAART, GBV-C-RNA titres decreased as HIV replication resumed. These findings further support the theory that GBV-C replication could depend on the dynamics of HIV progression.

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