Related Experiment Video

Updated: Jul 13, 2026

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
12:58

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

Published on: May 10, 2017

Pediatric pityriasis lichenoides and cutaneous T-cell lymphoma

Joseph Lam1, Elena Pope

  • 1Rady Children's Hospital, University of California, San Diego, San Diego, California, USA.

Current Opinion in Pediatrics
|July 17, 2007
PubMed

Insights

This review covers pityriasis lichenoides and pediatric cutaneous T-cell lymphoma, highlighting their spectrum and challenges. Understanding these childhood skin conditions is crucial for diagnosis and management.

Area of Science:

  • Pediatric Dermatology
  • Hematology-Oncology
  • Cutaneous Lymphoproliferative Disorders

Background:

  • Pityriasis lichenoides (PL) exists on a spectrum from acute to chronic forms.
  • Cutaneous T-cell lymphoma (CTCL) is a rare pediatric malignancy, often presenting in early stages with hypopigmentation.
  • Distinguishing between PL and pediatric CTCL can be challenging.

Purpose of the Study:

  • To educate readers on pityriasis lichenoides and pediatric cutaneous T-cell lymphoma.
  • To clarify the relationship between acute and chronic pityriasis lichenoides.
  • To highlight the diagnostic and therapeutic complexities of pediatric CTCL.

Main Methods:

  • Review of recent literature on pityriasis lichenoides.
  • Analysis of findings from an international registry of pediatric cutaneous T-cell lymphoma.
  • Synthesis of clinical presentations and management strategies.

Main Results:

  • Pityriasis lichenoides represents a benign lymphoproliferative spectrum.
  • Pediatric CTCL is characterized by early-stage disease and hypopigmented lesions.
  • Optimal investigation and treatment for pediatric CTCL remain subjects of debate.

Conclusions:

  • Readers will be able to identify pityriasis lichenoides and its variations.
  • Understanding the overlap between PL subtypes and its relation to CTCL is emphasized.
  • Appreciation for the diagnostic and treatment challenges in pediatric CTCL is fostered.
Abstract

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...