Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

meso-pyrimidinyl-substituted A2B-corroles.

Wouter Maes1, Thien H Ngo, Jeroen Vanderhaeghen

  • 1Molecular Design and Synthesis, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.

Organic Letters
|July 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of 1-(3-phenoxybenzyl)-4-(1-phenyl-1H-1,2,3-triazol-4-yl)piperidine analogues as potent and selective agonists of the human CC chemokine receptor 8.

European journal of medicinal chemistry·2026
Same author

Novel Aloe-Emodin Derivatives as Potential Anticancer Agents: Synthesis, Characterization and Cytotoxic Activity.

Molecules (Basel, Switzerland)·2026
Same author

Synthesis, structure-activity relationships, and SARS-CoV-2 antiviral activity of 3,5-disubstituted isothiazolo[4,3-<i>b</i>]pyridines as PIKfyve inhibitors.

Frontiers in chemistry·2026
Same author

Crystal Engineering of Intrinsic Dynamicity in Metal-Organic Frameworks for Adaptive Multicomponent Catalysis.

Angewandte Chemie (International ed. in English)·2026
Same author

A Stepwise Approach to 1,4,10,13-Tetraaza-18-Crown-6 Ether.

ChemistryOpen·2026
Same author

Affinity membranes in downstream bioprocessing: From chemical design rules to ligand engineering.

Journal of chromatography. A·2026
Same journal

Ir-Catalyzed Formal 1,2-Fluorine Migration in Fluorocarbenes.

Organic letters·2026
Same journal

Leveraging Bayesian Optimization for Accelerated Ligand Selection in Atroposelective Negishi Coupling.

Organic letters·2026
Same journal

Synthesis of Azido Energetic Compounds Based on 2-(Pyrazol-4-yl)pyrazolo[4,3-<i>e</i>][1,2,4]triazolo[1,5-<i>c</i>][1,2,3]triazine via an Atom-Economical Intramolecular Dutt-Wormall-Type Process.

Organic letters·2026
Same journal

Modular Synthesis of Dinitramino-Functionalized Pyrazole-Tetrazole and Its Derivatives: Achieving Superior Detonation Performance.

Organic letters·2026
Same journal

Light-Driven Iron-Catalyzed Decarboxylative Fluorosulfonylation of Aliphatic Carboxylic Acids.

Organic letters·2026
Same journal

Chiral Phosphoric Acid-Catalyzed Enantioselective Dearomative Spirocyclization of Phenol-Ynamides by Kinetic Resolution.

Organic letters·2026
See all related articles

New meso-pyrimidinyl-substituted A2B-corroles were synthesized using a Lewis acid-catalyzed condensation. Further modifications via cross-coupling reactions yielded sterically encumbered triarylcorroles with diverse substitution patterns.

Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry
  • Materials Science

Background:

  • Corroles are macrocyclic compounds with unique photophysical and electronic properties.
  • A2B-corroles are a specific isomer class with potential applications in catalysis and medicine.
  • Functionalization of corrole macrocycles is crucial for tuning their properties.

Purpose of the Study:

  • To synthesize novel meso-pyrimidinyl-substituted A2B-corroles.
  • To optimize reaction conditions for maximizing corrole yield.
  • To explore post-synthetic modification of these corroles via cross-coupling reactions.

Main Methods:

  • Condensation of 5-mesityldipyrromethane with 2-substituted 4,6-dichloropyrimidine-5-carbaldehydes.
  • Lewis acid catalysis (BF3.OEt2) optimization for A2B-corrole formation.

Related Experiment Videos

  • Copper metalation followed by nucleophilic aromatic substitution, Suzuki, Stille, and Liebeskind-Srogl cross-coupling reactions.

    • Main Results:

    • Meso-pyrimidinyl-substituted A2B-corroles were synthesized in good yields.
    • Optimized reduction of Lewis acid improved corrole yield.
    • Various cross-coupling reactions enabled the synthesis of sterically encumbered triarylcorroles and diverse pyrimidinyl substituent modifications.

    Conclusions:

    • A facile synthetic route to meso-pyrimidinyl-substituted A2B-corroles was established.
    • Post-synthetic modifications provide access to a wide range of functionalized corrole derivatives.
    • These novel corroles hold promise for applications requiring tailored electronic and steric properties.