Related Experiment Video
Updated: Jul 13, 2026
A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size
Published on: October 17, 2016
Covalent grafting of poly(L-lactide) to tune the in vitro degradation rate
Martina Källrot1, Ulrica Edlund, Ann-Christine Albertsson
1Fiber and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology, SE-100 44 Stockholm, Sweden.
Abstract:
The in vitro rate of degradation was purposely affected by covalently grafting the surface of poly(l-lactide) (PLLA). PLLA films were surface modified by our vapor-phase nondestructive photografting technique. Films were grafted for 20 min with one of the following monomers: acryl amide (AAm), N-vinyl pyrrolidone (VP), or acrylic acid (AA) and thereafter incubated in vitro in a phosphate-buffered saline solution at 37 degrees C for 154 days. The films were studied with contact angle measurements, SEM, ATR-FTIR, SEC, and DSC. The analyses verified that the in vitro rate of degradation was enhanced and that the grafted surface layer did remain covalently attached to the surface during the initial stages of incubation.
