Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Advancing stroke therapeutics through genetic understanding.

O A Ross1, B B Worrall, J F Meschia

  • 1Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.

Current Drug Targets
|July 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unstable Plaque is a Treatable Cause of Cognitive Decline.

Medical hypotheses·2024
Same author

Migraine-Associated Common Genetic Variants Confer Greater Risk of Posterior vs. Anterior Circulation Ischemic Stroke☆.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2022
Same author

Detailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study.

Journal of neurology·2019
Same author

Prevalence of Previously Undiagnosed Abdominal Aortic Aneurysms in Patients with Intracranial Aneurysms: From the Brain and Aortic Aneurysms Study (BAAS).

Neurocritical care·2019
Same author

Stroke-related epilepsy.

European journal of neurology·2018
Same author

Every physician should discourage cigarette smoking.

European journal of neurology·2018

Genetic factors significantly influence stroke risk and treatment response. Identifying genetic profiles in high-risk individuals can lead to targeted stroke prevention strategies and novel therapeutics.

Area of Science:

  • Neurology
  • Genetics
  • Pharmacogenomics

Background:

  • Stroke is a complex neurological disorder influenced by genetics, lifestyle, and environment.
  • Specific gene variations, such as in PDE4D and ALOX5AP, have been linked to increased stroke risk.
  • Further confirmation and identification of functional variants in these genes are needed.

Purpose of the Study:

  • To characterize the genetic profile of individuals at high risk of stroke.
  • To enable targeted pharmacological approaches for stroke prevention.
  • To explore genetic determinants of stroke outcomes for new therapeutic avenues.

Main Methods:

  • Genetic analysis of common variations in candidate genes.
  • Population-based risk assessment.

Related Experiment Videos

  • Pharmacogenomic studies.

    • Main Results:

    • Common variations in PDE4D and ALOX5AP genes identified as increasing population-attributable stroke risk in Iceland.
    • Genetic profiling can identify individuals at highest risk for targeted interventions.
    • Genetic determinants of stroke outcomes are being investigated.

    Conclusions:

    • Characterizing genetic profiles is crucial for personalized stroke prevention.
    • Pharmacogenomics, especially for anticoagulants like warfarin, is vital due to narrow therapeutic indices.
    • Identifying genetic factors can drive research into stroke therapeutics beyond current methods like thrombolysis.