Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Theoretical Cost-Effectiveness of PCSK9 Inhibitors in Stroke Due to Intracranial Atherosclerosis.

JAMA network open·2026
Same author

Optimal treatment of preclinical cardiovascular disease: A narrative review with a focus on carotid artery stenosis.

Seminars in vascular surgery·2026
Same author

Nonoperative management of patients with symptomatic carotid stenosis.

Seminars in vascular surgery·2026
Same author

Stroke Thrombectomy in the Elderly: Efficacy, Safety, and Special Considerations.

Stroke (Hoboken, N.J.)·2026
Same author

Trends in Thrombolysis and Thrombectomy Use in Patients With Ischemic Stroke and Cancer.

Stroke (Hoboken, N.J.)·2026
Same author

Atrial Fibrillation: Prevalence and Association With Outcome in Patients With Stroke Undergoing Mechanical Thrombectomy in the United States.

Stroke (Hoboken, N.J.)·2026

Related Experiment Video

Updated: Jul 13, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Prevention of ischemic stroke: surgery.

Kumar Rajamani1, Seemant Chaturvedi

  • 1Comprehensive Stroke Program, Department of Neurology, Wayne State University, Detroit, MI 48201, USA.

Current Drug Targets
|July 17, 2007
PubMed
Summary

Surgical intervention, like carotid endarterectomy, is effective for preventing ischemic stroke in patients with severe carotid artery stenosis. However, its benefit is less clear for moderate stenosis and not recommended for mild cases.

Area of Science:

  • Neurology
  • Vascular Surgery
  • Stroke Prevention

Background:

  • The past 15 years have seen a renewed focus on surgical interventions for preventing ischemic stroke.
  • Landmark trials like NASCET and ECST have evaluated carotid endarterectomy (CEA).

Purpose of the Study:

  • To review the efficacy of surgical options for ischemic stroke prevention.
  • To assess the role of carotid endarterectomy (CEA) in different grades of internal carotid artery (ICA) stenosis.
  • To explore surgical management for asymptomatic ICA stenosis and post-coronary artery bypass grafting (CABG) stroke.

Main Methods:

  • Review of landmark randomized trials (NASCET, ECST, ACAS, ACST).
  • Analysis of risk-benefit ratios for CEA in symptomatic and asymptomatic patients.

Related Experiment Videos

Last Updated: Jul 13, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

  • Evaluation of perioperative medical treatments and surgical approaches for carotid occlusion.

    • Main Results:

    • CEA significantly benefits patients with high-grade ICA stenosis (> or = 70%) and prior TIA/stroke.
    • Benefit is less pronounced in moderate stenosis (50-69%); surgery is not recommended for <50% stenosis.
    • Risk-benefit for asymptomatic ICA stenosis depends on low perioperative complication rates.
    • Aspirin shows benefit perioperatively; statins and betablockers require further study.
    • EC-IC bypass surgery shows promise for complete carotid occlusion and Moyamoya disease.

    Conclusions:

    • Carotid endarterectomy is a valuable stroke prevention tool for specific patient groups with significant ICA stenosis.
    • Further research is needed to optimize perioperative medical management and surgical strategies for carotid disease.
    • Surgical options for carotid occlusion and related conditions are gaining renewed interest.