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Updated: Jul 13, 2026
04:30
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Stenting and prevention of ischemic stroke
Mikael Mazighi1, Alex Abou-Chebl
1Interventional Neurology, Department of Neurology, University of Louisville, School of Medicine, Louisville, Kentucky, USA.
Current Drug Targets
|July 17, 2007
Summary
Carotid artery stenting offers a viable alternative to surgery for high-risk patients, with comparable stroke risks but fewer complications. Ongoing research explores its use in other cerebrovascular areas.
Area of Science:
- Neurology
- Vascular Surgery
- Interventional Cardiology
Background:
- Atherosclerosis-related ischemic strokes pose a significant health burden.
- Endovascular stenting is an emerging therapeutic option for cerebrovascular stenosis.
- Surgical intervention remains the standard for many cases, but carries specific risks.
Purpose of the Study:
- To review the current evidence and evolving role of stenting in cerebrovascular disease.
- To compare the safety and efficacy of carotid artery stenting (CAS) versus carotid endarterectomy (CEA).
- To explore the potential of stenting in extracranial vertebral and intracranial stenoses.
Main Methods:
- Review of prospective randomized trials comparing CAS and CEA.
- Analysis of outcomes data for stenting in various cerebrovascular locations.
- Evaluation of in-stent restenosis (ISR) rates and management strategies.
Main Results:
- CAS and CEA show similar peri-procedural stroke risks.
- CEA is associated with higher rates of nerve injury and myocardial infarction.
- Stenting may offer a better benefit/risk profile for symptomatic intracranial lesions compared to bypass surgery.
- ISR is infrequent after cervical CAS but common after vertebral and intracranial stenting.
Conclusions:
- Carotid artery stenting is a safe and effective alternative to surgery for high-risk patients with extracranial carotid stenosis.
- Further investigation is needed for stenting in other cerebrovascular territories.
- Drug-eluting stents show promise in managing ISR in cerebral vasculature.
- Advancements in endovascular devices will likely expand treatment options for cerebrovascular lesions.
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