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Updated: Jul 13, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Local delivery of proteins and the use of self-assembling peptides
Vincent F M Segers1, Richard T Lee
1Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.
Abstract:
Self-assembling peptides are members of a new class of molecules designed for tissue engineering and protein delivery. Upon injection in a physiological environment, self-assembling peptides form stable nanofiber hydrogels. Such biocompatible nanofibers can support three-dimensional growth and differentiation of many cell types. Self-assembling peptides are promising candidates for protein delivery, because they allow non-covalent binding of proteins, tethering of proteins, or incorporation of fusion proteins. Self-assembling peptides can be designed to deliver individual proteins or multiple factors, because the building blocks comprising self-assembling peptides can be designed with great flexibility.
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