Correlation of oxidative status with BMI and lung function in COPD
Arpana Vibhuti1, Ehtesham Arif, Desh Deepak
1Functional Genomics Unit, Institute of Genomics and Integrative Biology, Delhi, India.
Clinical Biochemistry
|July 17, 2007
Summary
Oxidative stress and low body weight are linked to chronic obstructive pulmonary disease (COPD) severity. This study found oxidative stress markers correlate with BMI and lung function in COPD patients.
Area of Science:
- Pulmonary Medicine
- Biochemistry
- Oxidative Stress Research
Background:
- Oxidative status imbalance, nutritional depletion, and low body weight are implicated in chronic obstructive pulmonary disease (COPD) pathogenesis and severity.
- Understanding the interplay between oxidative stress, body mass index (BMI), and lung function is crucial for managing COPD.
Purpose of the Study:
- To investigate the relationship between oxidative status and BMI in COPD patients.
- To examine the association of oxidative status and BMI with lung function (FEV(1)% predicted) in COPD.
Main Methods:
- Plasma lipid peroxidation (LPO), reduced glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT) activities were measured in 202 COPD patients and 136 healthy controls.
- Body Mass Index (BMI) and FEV(1)% predicted were assessed.
- Interactions and correlations between oxidative stress markers, BMI, and lung function were analyzed.
Main Results:
- COPD patients exhibited elevated LPO and decreased GSH, GPx, and CAT levels compared to controls.
- Oxidative stress markers significantly correlated with BMI and FEV(1)% predicted in COPD patients.
- A positive correlation was observed between BMI and FEV(1)% predicted in the COPD cohort.
Conclusions:
- A strong association exists between oxidative status, BMI, and lung function in COPD.
- The direct correlation between BMI and FEV(1) further suggests a complex relationship that may influence disease severity.
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