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Related Experiment Videos

Overactive bladder in children. Part 1: Pathophysiology.

Israel Franco1

  • 1Section of Pediatric Urology, Department of Urology, New York Medical College, Valhalla, New York, USA. Isfranco@optonline.net

The Journal of Urology
|July 17, 2007
PubMed
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Pediatric overactive bladder syndrome may stem from a central nervous system issue affecting multiple bodily systems, not just the bladder. This new understanding could lead to better treatments for children and adults with voiding dysfunction.

Area of Science:

  • Pediatric Urology
  • Neuroscience
  • Urogynecology

Background:

  • Detrusor overactivity, or overactive bladder syndrome, is a common pediatric voiding dysfunction.
  • Historically managed as a primary bladder issue or developmental delay.
  • Emerging evidence links it to broader neurological and systemic problems.

Purpose of the Study:

  • To explore the hypothesis that pediatric overactive bladder syndrome is a symptom of a more generalized, centrally located dysfunction.
  • To integrate findings from urology, neuroscience, and other fields to explain associated symptoms.

Main Methods:

  • Review of neuroanatomy, neurophysiology, and neuropharmacology of voiding.
  • Synthesis of existing research and clinical data from within and outside urology.

Related Experiment Videos

  • Development of a unified theory for pediatric overactive bladder syndrome and associated symptoms.

    • Main Results:

    • Pediatric overactive bladder syndrome and other voiding dysfunctions may be part of a multi-system disorder.
    • This disorder affects bowel, bladder, sexual function, blood pressure regulation, mood, and behavior.
    • Established links between bowel function and overactive bladder syndrome, as well as neuropsychiatric comorbidities.

    Conclusions:

    • Shifting from a bladder-centric to a brain-centric approach is crucial for understanding and treating pediatric overactive bladder syndrome.
    • Advanced brain imaging techniques will aid in diagnosis and treatment development.
    • Future treatments should target the underlying disease process, not just symptoms, for improved outcomes.