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Related Experiment Video

Updated: Jul 13, 2026

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring

Published on: April 3, 2015

Adventitia contribution to vascular contraction: hints provided by tissue-engineered substitutes.

François A Auger¹, Pédro D'Orléans-Juste, Lucie Germain

¹Laboratoire d'Organogénèse Expérimentale (LOEX), Hôpital du Saint-Sacrement du CHA, Québec, Canada. Francois.Auger@chg.ulaval.ca

Cardiovascular Research

|July 17, 2007

Summary

The adventitia, a vascular layer, plays a key role in physiology. Tissue-engineered vascular substitutes show this layer responds to vasoactive agents, aiding research.

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Last Updated: Jul 13, 2026

Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring

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Published on: April 3, 2015

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

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Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Area of Science:

Vascular biology and tissue engineering.

Background:

The adventitia's physiological role and mechanisms are not fully understood.
Research is limited by scarce healthy human vascular samples and isolation challenges.

Purpose of the Study:

To investigate the adventitia's contribution to vascular physiology.
To explore mechanisms using tissue-engineered vascular substitutes.

Main Methods:

Utilizing tissue-engineered vascular substitutes to model adventitial function.
Testing responses to vasoactive agents like endothelin and sodium nitroprusside.

Main Results:

Reconstructed adventitial layers in tissue-engineered models demonstrate responsiveness.
Vasoactive agents elicit responses in the engineered adventitia.

Conclusions:

Tissue-engineered vascular substitutes offer a viable model for studying adventitial physiology.
The adventitia actively participates in vascular responses to vasoactive stimuli.