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Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
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Published on: November 16, 2016

Interferon gamma: friend or foe?

Kathryn J Wood1, Gang Feng, Bin Wei

  • 1Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. kathryn.wood@nds.ox.ac.uk

Transplantation
|August 19, 2007
PubMed

Interferon gamma (IFN-gamma) can elicit an inflammatory TH1-driven immune response but has also been found to be necessary for long-term allograft survival induced by costimulation blockade. Recently, we have found that regulatory T cells rapidly and transiently produce IFN-gamma creating a microenvironment that can influence the function of antigen presenting cells (APCs), T-cell proliferation and activation as well as T-cell effector mechanisms, thereby controlling immune responses locally. Moreover, addition of IFN-gamma to cocultures of T cells and APCs can drive the generation of T cells with regulatory activity. Thus, the influence of IFN-gamma on the immune response to a transplant is likely to be context dependent.

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