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Updated: Jul 13, 2026
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Livin and Bcl-2 expression in high-grade osteosarcoma.
T Nedelcu1, B Kubista, A Koller
1Department of Orthopedic Surgery, Medical University of Vienna, Vienna General Hospital, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Nuclear Livin expression may serve as a prognostic marker for osteosarcoma patients. This study found nuclear Livin expression significantly correlated with decreased overall survival in osteosarcoma.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Prognosis evaluation in osteosarcoma currently relies on clinical parameters.
- Existing molecular markers lack routine clinical application for osteosarcoma prognosis.
Purpose of the Study:
- To investigate the expression of antiapoptotic proteins Livin and Bcl-2 in osteosarcoma.
- To determine if Livin and Bcl-2 can serve as prognostic markers in human osteosarcoma.
Main Methods:
- Immunohistochemistry was used to analyze Livin and Bcl-2 expression in 29 high-grade central osteosarcoma specimens.
- Expression patterns were correlated with histological response to chemotherapy and 5-year survival outcomes.
Main Results:
- Bcl-2 was expressed in the cytoplasm of 16/29 cases with no significant correlation to prognostic parameters.
- Livin was detected in 17/29 cases; nuclear Livin expression was significantly associated with decreased overall survival (P < 0.0002).
Conclusions:
- Both Bcl-2 and Livin are highly expressed in osteosarcoma cells.
- Nuclear Livin expression shows potential as a valuable prognostic marker for osteosarcoma.
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