Related Experiment Video

Updated: Jul 13, 2026

Modified Radical Neck Dissection for Cervical Metastasis
06:05

Modified Radical Neck Dissection for Cervical Metastasis

Published on: February 20, 2026

Treatment of advanced neck metastases

G Spriano1, R Pellini, V Manciocco

  • 1Department of Otolaryngology Head and Neck Surgery, National Cancer Institute Regina Elena, Rome, Italy. orl@ifo.it

Acta Otorhinolaryngologica Italica : Organo Ufficiale Della Societa Italiana Di Otorinolaringologia E Chirurgia Cervico-Facciale
|July 18, 2007
PubMed

Insights

Advanced cervical metastases (N2 and N3) indicate a poor prognosis. Combined treatment modalities, including surgery and radiochemotherapy, offer better cure chances than single treatments for neck cancer.

Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Radiation Oncology

Background:

  • Advanced cervical metastases (N2 and N3) are associated with poor prognosis and high failure rates.
  • Current treatment protocols for advanced neck disease often involve multimodality therapy.
  • Defining resectability and curability is challenging in N3 disease.

Purpose of the Study:

  • To review current treatment protocols for advanced cervical metastases.
  • To evaluate the efficacy of various combinations of surgery, radiotherapy, and chemotherapy.
  • To report on institutional experience in managing advanced neck disease.

Main Methods:

  • Literature review of studies on surgery, radiotherapy, and chemotherapy for advanced neck disease.
  • Analysis of different treatment associations and their outcomes.
  • Reporting of institutional experience with these treatment modalities.

Main Results:

  • Advanced cervical metastases are a significant poor prognostic factor.
  • Combined treatment modalities demonstrate superior oncological outcomes compared to single modalities.
  • Surgery followed by radiotherapy or chemoradiation is an effective, standardized approach.

Conclusions:

  • Multimodality treatment offers improved cure rates for advanced cervical metastases.
  • The role of planned neck dissection after chemoradiation remains a subject of debate.
  • Optimizing treatment strategies for advanced neck disease is crucial for improving patient outcomes.

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...