Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Percentage of Neutrophils and Neutrophil-to-Lymphocyte Ratio in Distinguishing Late from Early Prehospital Presentation of Perforated Appendicitis in Children.

Nigerian journal of clinical practice·2025
Same author

Utility of MRI in detection of PET-CT proven local recurrence of pancreatic adenocarcinoma after surgery.

Medical oncology (Northwood, London, England)·2024
Same author

Supplementary orthopaedic screening for children and adolescents to prevent permanent skeletal deformities - protocol for the "OrthoKids" study.

BMC musculoskeletal disorders·2023
Same author

Evaluation of the self-assessment knowledge regarding cardiopulmonary resuscitation in medical students at the University of Belgrade.

European review for medical and pharmacological sciences·2023
Same author

Correlation between increased maternal body mass index and pregnancy complications.

European review for medical and pharmacological sciences·2023
Same author

Psoriasis patients' characteristics associated with high PASI response to tildrakizumab: an international dual center study.

European review for medical and pharmacological sciences·2022

Related Experiment Video

Updated: Jul 13, 2026

Massive Pontine Hemorrhage by Dual Injection of Autologous Blood
06:33

Massive Pontine Hemorrhage by Dual Injection of Autologous Blood

Published on: May 29, 2021

[Coagulopaty in associated with massive transfusion].

B Jovanović1, V Bumbasirević, Z Terziski

  • 1Institut za Anesteziju i Reanimaciju, Urgentni centar, KCS, Beograd.

Acta Chirurgica Iugoslavica
|July 20, 2007
PubMed
Summary

Massive hemorrhage management requires careful attention to coagulopathy during large-volume resuscitation. Maintaining normal body temperature is key to improving hemostasis and patient outcomes.

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Related Experiment Videos

Last Updated: Jul 13, 2026

Massive Pontine Hemorrhage by Dual Injection of Autologous Blood
06:33

Massive Pontine Hemorrhage by Dual Injection of Autologous Blood

Published on: May 29, 2021

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Area of Science:

  • Anesthesiology
  • Trauma Surgery
  • Hemorrhage Management

Background:

  • Massive hemorrhage presents significant challenges in both elective and trauma settings.
  • Anesthesia providers manage large-volume resuscitations, often leading to coagulopathy.
  • Coagulopathy in massive transfusion is multifactorial, including hemodilution and hypothermia.

Purpose of the Study:

  • To review the challenges of massive hemorrhage management.
  • To discuss the causes and management of coagulopathy during massive transfusion.
  • To highlight effective strategies for improving hemostasis.

Main Methods:

  • Literature review on massive hemorrhage and transfusion protocols.
  • Analysis of factors contributing to coagulopathy.
  • Discussion of treatment strategies for hemostasis.

Main Results:

  • Large-volume resuscitation can induce coagulopathy.
  • Hypothermia, hemodilution, and disseminated intravascular coagulation are key factors.
  • Maintaining normal body temperature is a critical first-line strategy.

Conclusions:

  • Effective management of massive hemorrhage involves addressing coagulopathy.
  • Strategies include maintaining tissue perfusion, correcting anemia, and using hemostatic blood products.
  • Normal body temperature is crucial for improving hemostasis.