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Updated: Jul 13, 2026

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
Published on: January 31, 2022
[Iron deficiency anemia and its importance in gastroenterology clinical practise]
D Vucelić1, B Nenadić, P Pesko
1Klinika za digestivnu hirurgiju, Institut za bolesti digestivnog sistema, KCS, Beograd.
Insights
Iron deficiency anemia (IDA) is a widespread issue affecting all ages, often stemming from gastrointestinal bleeding or pregnancy. Prompt diagnosis and treatment, including endoscopic evaluation, are crucial for managing this common anemia.
Area of Science:
- Hematology
- Internal Medicine
- Gastroenterology
Context:
- Iron deficiency anemia (IDA) is a prevalent global health concern affecting diverse populations.
- It is a frequent reason for medical consultations and a common type of anemia.
- IDA significantly impacts child development and maternal health, including risks of postpartum depression.
Purpose:
- To highlight the significance of iron deficiency anemia (IDA) as a universal health problem.
- To emphasize the diagnostic challenges and the importance of appropriate investigation for IDA.
- To underscore the necessity of understanding iron metabolism for effective management.
Summary:
- Chronic occult gastrointestinal bleeding is a primary cause of IDA in adults.
- A significant percentage of IDA patients have serious gastrointestinal lesions, including malignancies, detected via endoscopy.
- Many patients with IDA are not adequately tested for iron deficiency or do not receive recommended endoscopic evaluations.
Impact:
- Highlights the critical need for comprehensive diagnostic workups in IDA patients.
- Stresses the importance of endoscopic evaluation to identify underlying gastrointestinal pathologies.
- Emphasizes that appropriate treatment involves replenishing iron stores and addressing the root cause of IDA.
Abstract:
Iron deficiency anemia (IDA) is a universal problem involving individuals of all ages and both sexes and is a common cause of referral to medical departments. This anemia is one of the most common types of anemia. IDA impairs growth and intellectual development in children and adolescent. In women IDA is most common in reproductive period because of menstrual and pregnancy iron losses. IDA affects roughly 10-30% of all pregnancies and, among others morbidities, may contribute of developing postpartum depression. Among other adult patient, chronic occult gastrointestinal bleeding is the leading cause of IDA. Approximately, one third of patients with anemia have iron deficiency and up to two thirds of patients with IDA have serious gastrointestinal lesions detected with esophagogastroduodenoscopy and colonoscopy, including 10-15% with malignancy. However, in practice not all anemic patients undergo appropriate diagnostic tests to detect iron deficiency. Furthermore, a substantial proportion of patients with IDA do not undergo endoscopic evaluation. The approach to its investigation and subsequent therapy depends upon a comprehensive understanding of iron metabolism and heme synthesis. Once diagnosis of iron deficiency or IDA is established, evaluation for the cause of anemia must be appropriate performed and treatment must include corrective replenishment of body stores.
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