[Clinical observation on effect of xian-zhong injection on treating primary knee OA]

To research and evaluate the clinical efficacy of Xian-zhong injection in treating primary knee OA.

By using Lequesne instituted ISOA and Kellgren-Lawrance instituted X-ray class standard, 127 non-operation primaary knee OA patients were divided into three grades (Light, Moderate, Severe). To adopt randomized single controlled trial, each grade was divided into two groups, respectively injected Xian-zhong injection or Sodium Hyaluronate injection. Every injection's volume was 2 ml and injected one per week, then consecutively injected one month. Finally we followed up in the first month, third month, sixth month, afterward we did every six months.

After followed up one - twenty-four months we found ISOA score less than thirteen and K-LA X-ray class standard less than III grade, the clinical efficacy of two kind of injections was better. But ISOA score more than thirteen and K-LA X-ray class standard mord than III grade, the clinical efficacy was bad. The follow-up showed that the total effective rate and excellent rate between Xian-zhong injection group and Sodium Hyaluronate injection group weren't significantly different.

Xian-zhong injection can improve the clinical efficacy of primary knee OA, it has the greatest researching value and using furthermore.