Related Experiment Video
Updated: Jul 13, 2026

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
Can an educational program optimize PDE5i therapy? A study of Canadian primary care practices
Gerald Brock1, Serge Carrier, Richard Casey
1Department of Urology, St. Joseph's Healthcare, London, Ontario, Canada.
A new educational program for erectile dysfunction (ED) patients using sildenafil did not significantly improve treatment satisfaction scores compared to usual care. However, patients and physicians found the educational materials valuable.
Area of Science:
- Urology
- Primary Care Medicine
- Health Education
Background:
- Optimizing therapy with phosphodiesterase type 5 inhibitors is crucial for erectile dysfunction (ED) treatment.
- Patient instructions play a key role in enhancing treatment efficacy.
Purpose of the Study:
- To evaluate the impact of an educational program (Treatment Optimization Program - TOP) for new sildenafil users.
- To compare the TOP tool against usual ED management in Canadian primary care.
Main Methods:
- A multicenter, 6-month cluster randomized prospective study involving 2,573 men naive to sildenafil.
- Sites were randomized to receive the TOP tool (brochure, video) or usual care.
- Treatment satisfaction assessed using the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) at 3 and 6 months.
Main Results:
- High overall treatment satisfaction with sildenafil (9/10 patients).
- No significant difference in EDITS scores between the TOP and non-TOP groups.
- High patient satisfaction with TOP materials (video, brochure) and physician willingness to use the tool (84%).
Conclusions:
- The Treatment Optimization Program (TOP) is a valuable tool for managing newly diagnosed ED patients.
- TOP offers time-efficient benefits for both patients and physicians in ED management.
- While not improving EDITS scores, the educational components were well-received.
Related Concept Videos
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions
Peripheral Artery Disease III: Interprofessional Care
Dosage Regimens: Designs and Approaches
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Coronary Artery Disease V: Interprofessional Care
